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Type I Signal Peptidase and Protein Secretion in Staphylococcus aureus

23 Mar 2012

Abstract excerpt

Staphylococcus aureus is an important human pathogen whose virulence relies on the secretion of many different proteins. In general, the secretion of most proteins in S. aureus, as well as other bacteria, is dependent on the type I signal peptidase (SPase)-mediated cleavage of the N-terminal signal peptide that targets a protein to the general secretory pathway. The arylomycins are a class of natural product...

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PMID: 22447899
DOI: 10.1128/jb.00064-12

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