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A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant <em>Staphylococcus aureus</em> (MRSA)

2023-09-13

Abstract excerpt

Staphylococcus aureus is a common pathogen in human. Methicillin resistant Staphylococcus aureus (MRSA) infection poses a big and perplexing difficulty in terms of therapy. The acquisition of the non-native gene PBP2a, which has a decreased tolerance for &beta;-lactam antibiotics, frequently confers resistance. PBP2a has a less attraction for methicillin and it helps bacteria to continue peptidoglycan biosynthesis...

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Literature Corpus work
a443bea5-7db1-578d-abb0-1b961f5e4300
DOI
10.20944/preprints202309.0856.v1
Open publication

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A Review on Five and Six-Membered Heterocyclic Compounds Targeting the Penicillin-Binding Protein 2 (PBP2A) of Methicillin-Resistant <em>Staphylococcus aureus</em> (MRSA)DOI 10.20944/preprints202309.0856.v1
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