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A benzoxazolylurea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant <i>Staphylococcus aureus</i>

2023-09-03

Abstract excerpt

<h4>ABSTRACT</h4> Vancomycin intermediate-resistant Staphylococcus aureus (VISA) is a pathogen of concern. VraS, a histidine kinase, facilitates the VISA phenotype. Here, we reveal a benzoxazolylurea that directly inhibits VraS and enhances vancomycin to below the clinical breakpoint against an archetypal VISA strain. To the best of our knowledge, this is the first direct VraS inhibitor ever reported that shows s...

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Literature Corpus work
1718c8e1-787f-5d02-8c50-68b0bb970abd
DOI
10.1101/2023.08.31.555806
Open publication

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A benzoxazolylurea inhibits VraS and enhances antimicrobials against vancomycin intermediate-resistant <i>Staphylococcus aureus</i>DOI 10.1101/2023.08.31.555806
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