Article
Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.
Journal of virology - 1 Nov 2007
Brockman Mark A, Schneidewind Arne, Lahaie Matthew, Schmidt Aaron, Miura Toshiyuki, Desouza Ivna, Ryvkin Faina, Derdeyn Cynthia A, Allen Susan, Hunter Eric, Mulenga Joseph, Goepfert Paul A, Walker Bruce D, Allen Todd M
Abstract excerpt
Certain histocompatibility leukocyte antigen (HLA) alleles are associated with improved clinical outcomes for individuals infected with human immunodeficiency virus type 1 (HIV-1), but the mechanisms for their effects remain undefined. An early CD8(+) T-cell escape mutation in the dominant HLA-B5...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.