Article
Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cells.
Journal of virology - 1 Oct 2010
Payne Rebecca P, Kløverpris Henrik, Sacha Jonah B, Brumme Zabrina, Brumme Chanson, Buus Søren, Sims Stuart, Hickling Stephen, Riddell Lynn, Chen Fabian, Luzzi Graz, Edwards Anne, Phillips Rodney, Prado Julia G, Goulder Philip J R
Abstract excerpt
The association between HLA-B 2705 and the immune control of human immunodeficiency virus type 1 (HIV-1) has previously been linked to the targeting of the HLA-B 2705-restricted Gag epitope KRWIILGLNK (KK10) by CD8(+) T cells. In order to better define the mechanisms of the HLA-B 2705 immune control of HIV, we first characterized the CD8(+) T-cell responses of nine highly active antiretroviral therapy...
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