[Control of HIV infection and selection/ accumulation of HIV escape mutants by HIV-specific cytotoxic T lymphocytes (CTLs)].

Abstract excerpt

HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in control of HIV infection. HLA class I molecules, which mediate recognition of HIV-infected cells by the CTLs, have great diversity. Some HLA class I molecules are well known to associate with HIV control. HIV escapes from the CTLs through amino acid mutations within CTL epitopes. The rapid and extensive spread of HIV escape mutants provides...

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