Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

The Journal of cell biology - 1 Sept 1990

Paterson H F, Self A J, Garrett M D, Just I, Aktories K, Hall A

Abstract excerpt

The rho proteins, p21rho, are ubiquitously expressed guanine nucleotide binding proteins with approximately 30% amino acid homology to p21ras, but their biochemical function is unknown. We show here that microinjection of constitutively activated recombinant rho protein (Val14rho) into subconfluent cells induces dramatic changes in cell morphology: 15-30 min after injection cells adopt a distinct and novel...

Topics

Adenosine Diphosphate Ribose
Animals
Cell Adhesion
Cells, Cultured
Cytoskeleton
GTP Phosphohydrolases
GTP-Binding Proteins
Membrane Proteins
Microinjections
Mutation
Recombinant Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rhoA GTP-Binding Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 2118140
DOI: 10.1083/jcb.111.3.1001
PMCID: PMC2116288

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2118140-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microinjection of recombinant p21rho induces rapid changes in cell morphology.PMID 2118140Read ↗

The Small GTP-binding Protein Rho Regulates Cortical Activities in Cultured Cells during DivisionSemantic proximity Read ↗

Establishment of stable human fibroblast cell lines constitutively expressing active Rho-GTPases.Semantic proximity Read ↗

Cell type-specific regulation of RhoA activity during cytokinesis.Semantic proximity Read ↗

Nano-mechanical properties of living cells expressing constitutively active RhoA effectors.Semantic proximity Read ↗

Rho-stimulated contractility contributes to the fibroblastic phenotype of Ras-transformed epithelial cells.Semantic proximity Read ↗

B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase.Semantic proximity Read ↗

Rapid activation of Rac GTPase in living cells by force is independent of Src.Semantic proximity Read ↗

Rho controls actin cytoskeletal assembly in renal epithelial cells during ATP depletion and recovery.Semantic proximity Read ↗

A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival.Semantic proximity Read ↗

Rac is required for growth cone function but not neurite assembly.Semantic proximity Read ↗

Regulation of p190 Rho-GAP by v-Src is linked to cytoskeletal disruption during transformationSemantic proximity Read ↗

Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.