Article
B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase.
Molecular biology of the cell - 1 Jun 1998
Aarts L H, Schrama L H, Hage W J, Bos J L, Gispen W H, Schotman P
Abstract excerpt
In the present study we show that expression of the neural PKC-substrate B-50 (growth-associated protein [GAP-43]) in Rat-1 fibroblasts induced the formation of filopodial extensions during spreading. This morphological change was accompanied by an enhanced formation of peripheral actin filaments...
Topics
- Animals
- Cell Cycle Proteins
- Cell Line
- Cell Movement
- Enzyme Activation
- Fibroblasts
- GAP-43 Protein
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Gene Expression
- Morphogenesis
- Mutagenesis
- Organelles
- Phenotype
- Rats
- cdc42 GTP-Binding Protein
- rac GTP-Binding Proteins
- rho GTP-Binding Proteins