Article
B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase.
Molecular biology of the cell - 1 Jun 1998
Aarts L H, Schrama L H, Hage W J, Bos J L, Gispen W H, Schotman P
Abstract excerpt
In the present study we show that expression of the neural PKC-substrate B-50 (growth-associated protein [GAP-43]) in Rat-1 fibroblasts induced the formation of filopodial extensions during spreading. This morphological change was accompanied by an enhanced formation of peripheral actin filaments and by accumulation of vinculin immunoreactivity in filopodial focal adhesions, colocalizing with B-50. In time lapse...
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