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Article

Rac is required for growth cone function but not neurite assembly.

Journal of cell science - 1 Mar 1997

Lamoureux P, Altun-Gultekin Z F, Lin C, Wagner J A, Heidemann S R

Abstract excerpt

Recent work has suggested that rac1 and other members of the rho family of small GTP-binding proteins play an important role in the formation of neural processes. We have explored the mechanism of this effect by comparing the spontaneous, growth cone-mediated growth and experimental tension-induced growth of axons in normal PC12 cells and in mutant cells expressing a dominant negative form of rac. PC12 that have...

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Source

Identifiers

PMID: 9092945
DOI: 10.1242/jcs.110.5.635

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Rac is required for growth cone function but not neurite assembly.PMID 9092945Read ↗

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Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells.Semantic proximity Read ↗

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Divergent regulation of GAP-43 expression and CNS neurite outgrowth by cyclic AMP.Semantic proximity Read ↗

Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1.Semantic proximity Read ↗

Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.Semantic proximity Read ↗

Rho and Ras GTPases in axon growth, guidance, and branching.Semantic proximity Read ↗

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