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Article

Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho.

The Journal of biological chemistry - 18 Jun 1999

Sekimata M, Kabuyama Y, Emori Y, Homma Y

Abstract excerpt

We recently cloned a novel signaling molecule, p122, that shows a GTPase-activating activity specific for Rho and the ability to enhance the phosphatidylinositol 4,5-bisphosphate-hydrolyzing activity of phospholipase C delta1 in vitro. Here we analyzed the in vivo function of p122. Microinjection of the GTPase-activating domain of p122 suppressed the formation of stress fibers and focal adhesions induced by...

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Identifiers

PMID: 10364218
DOI: 10.1074/jbc.274.25.17757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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