Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho.

doi:10.1074/jbc.274.25.17757

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Article

Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho.

The Journal of biological chemistry - 18 Jun 1999

Sekimata M, Kabuyama Y, Emori Y, Homma Y

Abstract excerpt

We recently cloned a novel signaling molecule, p122, that shows a GTPase-activating activity specific for Rho and the ability to enhance the phosphatidylinositol 4,5-bisphosphate-hydrolyzing activity of phospholipase C delta1 in vitro. Here we analyzed the in vivo function of p122. Microinjection of the GTPase-activating domain of p122 suppressed the formation of stress fibers and focal adhesions induced by...

Topics

Amino Acid Sequence
Aniline Compounds
Animals
Calcium
Cell Adhesion
Cell Line
Cell Size
Cytoskeleton
Enzyme Activation
GTP-Binding Proteins
GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isoenzymes

Lysophospholipids

Molecular Sequence Data

Mutation

Phosphatidylinositol 4,5-Diphosphate

Phospholipase C delta

Plasmids

Source

Open in PubMed

Identifiers

PMID: 10364218
DOI: 10.1074/jbc.274.25.17757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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