Article
Zebrafish numb and numblike are involved in primitive erythrocyte differentiation.
PloS one - 13 Dec 2010
Bresciani Erica, Confalonieri Stefano, Cermenati Solei, Cimbro Simona, Foglia Efrem, Beltrame Monica, Di Fiore Pier Paolo, Cotelli Franco
Abstract excerpt
BACKGROUND: Notch signaling is an evolutionarily conserved regulatory circuitry implicated in cell fate determination in various developmental processes including hematopoietic stem cell self-renewal and differentiation of blood lineages. Known endogenous inhibitors of Notch activity are Numb-Nb and Numblike-Nbl, which play partially redundant functions in specifying and maintaining neuronal differentiation. Nb...
Topics
- Animals
- Cell Differentiation
- Cell Lineage
- Dose-Response Relationship, Drug
- Erythrocytes
- Evolution, Molecular
- Gene Expression Regulation, Developmental
- Hematopoiesis
- Membrane Proteins
- Nerve Tissue Proteins
- Phenotype
- Plasmids
- Protein Biosynthesis