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Article

Zebrafish numb and numblike are involved in primitive erythrocyte differentiation.

PloS one - 13 Dec 2010

Bresciani Erica, Confalonieri Stefano, Cermenati Solei, Cimbro Simona, Foglia Efrem, Beltrame Monica, Di Fiore Pier Paolo, Cotelli Franco

Abstract excerpt

BACKGROUND: Notch signaling is an evolutionarily conserved regulatory circuitry implicated in cell fate determination in various developmental processes including hematopoietic stem cell self-renewal and differentiation of blood lineages. Known endogenous inhibitors of Notch activity are Numb-Nb and Numblike-Nbl, which play partially redundant functions in specifying and maintaining neuronal differentiation. Nb...

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Identifiers

PMID: 21179188
DOI: 10.1371/journal.pone.0014296
PMCID: PMC3001437

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Source receipt: pubmed, retrieved 7 Sept 2026.

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