Article
Notch signaling distinguishes 2 waves of definitive hematopoiesis in the zebrafish embryo.
Blood - 8 Apr 2010
Bertrand Julien Y, Cisson Jennifer L, Stachura David L, Traver David
Abstract excerpt
Recent studies have revealed that definitive hematopoiesis in vertebrates initiates through the formation of a non-self-renewing progenitor with limited multilineage differentiation potential termed the erythromyeloid progenitor (EMP). EMPs are specified before hematopoietic stem cells (HSCs), which self-renew and are capable of forming all mature adult blood lineages including lymphoid cells. Despite their...
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