Article
Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish.
Developmental cell - 1 Jan 2005
Rhodes Jennifer, Hagen Andreas, Hsu Karl, Deng Min, Liu Ting Xi, Look A Thomas, Kanki John P
Abstract excerpt
The zebrafish is a powerful model system for investigating embryonic vertebrate hematopoiesis, allowing for the critical in vivo analysis of cell lineage determination. In this study, we identify zebrafish myeloerythroid progenitor cells (MPCs) that are likely to represent the functional equivalent of mammalian common myeloid progenitors. Utilizing transgenic pu.1-GFP fish, real-time MPC differentiation was...
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