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The role of meis1 in primitive and definitive hematopoiesis during zebrafish development

3 Nov 2010

Abstract excerpt

BACKGROUND: The Meis1 protein represents an important cofactor for Hox and Pbx1 and is implicated in human and murine leukemias. Though much is known about the role of meis1 in leukemogenesis, its function in normal hematopoiesis remains largely unclear. Here we characterized the role of the proto-oncogene, meis1, during zebrafish primitive and definitive hematopoiesis. DESIGN AND METHODS: Zebrafish embryos were...

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PMID: 21048033
DOI: 10.3324/haematol.2010.027698

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