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Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome

4 Oct 2012

Abstract excerpt

To identify genes that contribute to chemotherapy resistance in glioblastoma, we conducted a synthetic lethal screen in a chemotherapy-resistant glioblastoma-derived cell line with the clinical alkylator temozolomide (TMZ) and an siRNA library tailored toward "druggable" targets. Select DNA repair genes in the screen were validated independently, confirming the DNA glycosylases uracil-DNA glycosylase (UNG) and...

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PMID: 23038810
DOI: 10.1158/1541-7786.mcr-12-0168

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