Article
A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003
Huang Meng-Er, Rio Anne-Gaelle, Nicolas Alain, Kolodner Richard D
Abstract excerpt
A genomewide screen of a collection of 4,847 yeast gene deletion mutants was carried out to identify the genes required for suppressing mutations in the CAN1 forward-mutation assay. The primary screens and subsequent analysis allowed (i) identification of 18 known mutator mutants, providing a solid means for checking the efficiency of the screen, and (ii) identification of a number of genes not known previously...
Topics
- Base Sequence
- DNA, Fungal
- Genome, Fungal
- Mutation
- Phenotype
- Saccharomyces cerevisiae