Article
Identification of a distinctive mutation spectrum associated with high levels of transcription in yeast.
Molecular and cellular biology - 1 Jun 2004
Lippert Malcolm J, Freedman Jennifer A, Barber Melissa A, Jinks-Robertson Sue
Abstract excerpt
High levels of transcription are associated with increased mutation rates in Saccharomyces cerevisiae, a phenomenon termed transcription-associated mutation (TAM). To obtain insight into the mechanism of TAM, we obtained LYS2 forward mutation spectra under low- versus high-transcription conditions in which LYS2 was expressed from either the low-level pLYS2 promoter or the strong pGAL1-10 promoter, respectively....
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