Article

A naturally-occurring dominant-negative competitor of Keap1 against its inhibition of Nrf2

2018-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Transcription factor Nrf2 is a master regulator of antioxidant and/or electrophile response elements (AREs/EpREs)driven genes involved in homeostasis, detoxification and adaptation to various stresses. The cytoprotective activity of Nrf2, though being oppositely involved in both cancer prevention and progression, is critically controlled by Keap1 (Kelch-like ECH-associated protein 1) as an adapt...

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Literature Corpus work: d9eba3f9-8fd7-5db1-be38-055743609761
DOI: 10.1101/286997

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