Article
1173C>T polymorphism in VKORC1 modulates the required warfarin dose.
Pediatric cardiology - 1 Jan 2000
Kosaki K, Yamaghishi C, Sato R, Semejima H, Fuijita H, Tamura K, Maeyama K, Yamagishi H, Sugaya A, Dodo H, Tanigawara Y, Takahashi T
Abstract excerpt
The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We evaluted the effect of VKORC1 polymorphisms on warfarin response among Japanese, taking advantage of its unique population structure in which CYP2C9 *2 and *3 alleles are relatively rare. Thirty-one patients (12-34 years old; median, 22) on warfarin were recruited from a pediatric cardiology...
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