Article
[Vitamin K epoxide reductase complex 1 gene polymorphism and warfarin dose requirement in Chinese patients].
Zhonghua xin xue guan bing za zhi - 1 Jul 2007
Jiang Nian-xin, Song Jie, Xu Biao
Abstract excerpt
OBJECTIVE: To investigate the possible relationship between vitamin K epoxide reductase complex 1 (VKORC1) gene polymorphism and warfarin dose requirements in Chinese patients. METHOD: Genotyping for the C1173T polymorphism in the VKORC1 gene was performed using a restriction enzyme digestion of PCR-amplified DNA in 102 Chinese patients treated with warfarin. RESULTS: TT genotype was found in 83 patients (81.4%),...
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