Article

Viral diversity is an obligate consideration in CRISPR/Cas9 designs for HIV cure

2018-01-27

Abstract excerpt

RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies to date have focused on molecular clones with ideal target site recognition and do not account for target site variability observed within and between patients. For clinical success and broad applicability, g...

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Literature Corpus work: 193d36ff-d754-506d-8035-8a3f0dac7f0c
DOI: 10.1101/255133

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