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Article

Functional conservation of HIV-1 Gag: implications for rational drug design.

Retrovirology - 31 Oct 2013

Li Guangdi, Verheyen Jens, Rhee Soo-Yon, Voet Arnout, Vandamme Anne-Mieke, Theys Kristof

Abstract excerpt

BACKGROUND: HIV-1 replication can be successfully blocked by targeting gag gene products, offering a promising strategy for new drug classes that complement current HIV-1 treatment options. However, naturally occurring polymorphisms at drug binding sites can severely compromise HIV-1 susceptibility to gag inhibitors in clinical and experimental studies. Therefore, a comprehensive understanding of gag natural...

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Share to Amino Acid Sequence
Share to Anti-HIV Agents
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

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Share to Mutation, Missense

Share to Virus Replication

Source

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Identifiers

PMID: 24176092
DOI: 10.1186/1742-4690-10-126
PMCID: PMC4228425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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