Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic reversion of cisplatin resistance in human cells accompanies reduced host cell reactivation of damaged plasmid.

Biochemical and biophysical research communications - 31 Jul 1990

Chao C C, Lee Y L, Lin-Chao S

Abstract excerpt

Revertant cell lines were established from cisplatin (CP) resistant HeLa cells. Expression of CP damaged plasmid DNA carrying bacterial chloramphenicol acetyltransferase (CAT) gene after transfection into cells was measured. Revertant cells showed reduced host cell reactivation of damaged plasmid, as compared to resistant cells. Addition of aphidicolin, an inhibitor for DNA polymerase alpha, to resistant cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA
Share to Cell Survival
Share to DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Drug Resistance

Share to HeLa Cells

Share to Phenotype

Share to Plasmids

Source

Identifiers

PMID: 2116798
DOI: 10.1016/0006-291x(90)92169-z

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic reversion of cisplatin resistance in human cells accompanies reduced host cell reactivation of damaged plasmid.PMID 2116798Read ↗

Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants.Semantic proximity Read ↗

Characterization of a cAMP-dependent protein kinase mutant resistant to cisplatin.Semantic proximity Read ↗

Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.Semantic proximity Read ↗

Characterization of revertants of the CHO EM9 mutant arising during DNA transfection.Semantic proximity Read ↗

Characterization of promoter elements involved in the down-regulation of topoisomerase IIalpha expression in a drug-resistant cell line.Semantic proximity Read ↗

Characterization of auromomycin-resistant hamster cell mutants that display a multidrug resistance phenotype.Semantic proximity Read ↗

Transfection of 9-hydroxyellipticine-resistant Chinese hamster fibroblasts with human topoisomerase IIalpha cDNA: selective restoration of the sensitivity to DNA religation inhibitors.Semantic proximity Read ↗

Cisplatin resistance in cyclic AMP-dependent protein kinase mutants.Semantic proximity Read ↗

Activation of tumor suppressor genes in nontumorigenic revertants of the HeLa cervical carcinoma cell line.Semantic proximity Read ↗

Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells.Semantic proximity Read ↗

Nalidixic acid-resistant V79 cells with reduced DNA topoisomerase II activity and amplification prone phenotype.Semantic proximity Read ↗

Aphidicolin-resistant Chinese hamster ovary cells possess altered DNA polymerases of the alpha-family.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.