Phenotypic reversion of cisplatin resistance in human cells accompanies reduced host cell reactivation of damaged plasmid.

doi:10.1016/0006-291x(90)92169-z

Back to search

Article

Phenotypic reversion of cisplatin resistance in human cells accompanies reduced host cell reactivation of damaged plasmid.

Biochemical and biophysical research communications - 31 Jul 1990

Chao C C, Lee Y L, Lin-Chao S

Abstract excerpt

Revertant cell lines were established from cisplatin (CP) resistant HeLa cells. Expression of CP damaged plasmid DNA carrying bacterial chloramphenicol acetyltransferase (CAT) gene after transfection into cells was measured. Revertant cells showed reduced host cell reactivation of damaged plasmid...

Topics

Aphidicolin
Cell Survival
Cisplatin
DNA
DNA Damage
DNA Repair
Diterpenes
Dose-Response Relationship, Drug
Drug Resistance
HeLa Cells
Humans
Phenotype
Plasmids

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.