Article
Characterization of auromomycin-resistant hamster cell mutants that display a multidrug resistance phenotype.
Molecular pharmacology - 1 Aug 1990
Rauscher F J, Beerman T A, Baker R M
Abstract excerpt
We have selected and characterized Chinese hamster ovary (CHO) cells resistant to auromomycin (AUR), an antitumor antibiotic composed of a protein moiety and a nonpeptide chromophore. AUR is cytotoxic as a consequence of DNA strand-scission activity associated with the chromophore. Initial single...
Topics
- Animals
- Anti-Bacterial Agents
- Antibiotics, Antineoplastic
- Blotting, Southern
- Cell Division
- Cell Line
- Cricetinae
- DNA
- DNA Damage
- Drug Resistance
- Mutation
- Peptides
- Zinostatin