TP53 and mutations in human cancer.

Abstract excerpt

TP53 is the most frequently mutated gene in human cancer, with a predominance of missense mutations scattered over 200 codons. In many cancers, specific mutation patterns can be identified, which are shaped by site-specific mutagenesis and by biological selection. In tobacco-related cancers (lung, head and neck), organ-specific patterns are observed, with many mutations compatible with the ones experimentally...

Topics

• Environment
• Genes, p53
• Geography
• Humans
• Incidence
• Mutation
• Mutation, Missense
• Neoplasms