Article
Predictive testing for complex diseases using multiple genes: fact or fiction?
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2006
Janssens A Cecile J W, Aulchenko Yurii S, Elefante Stefano, Borsboom Gerard J J M, Steyerberg Ewout W, van Duijn Cornelia M
Abstract excerpt
PURPOSE: There is ongoing debate about whether testing low-risk genes at multiple loci will be useful in clinical care and public health. We investigated the usefulness of multiple genetic testing using simulated data. METHODS: Usefulness was evaluated by the area under the receiver-operating characteristic curve (AUC), which indicates the accuracy of genetic profiling in discriminating between future patients...
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