Article
BiForce Toolbox: powerful high-throughput computational analysis of gene-gene interactions in genome-wide association studies.
Nucleic acids research - 1 Jul 2012
Gyenesei Attila, Moody Jonathan, Laiho Asta, Semple Colin A M, Haley Chris S, Wei Wen-Hua
Abstract excerpt
Genome-wide association studies (GWAS) have discovered many loci associated with common disease and quantitative traits. However, most GWAS have not studied the gene-gene interactions (epistasis) that could be important in complex trait genetics. A major challenge in analysing epistasis in GWAS is the enormous computational demands of analysing billions of SNP combinations. Several methods have been developed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.