Article
Analysis of gene-gene interactions.
Current protocols in human genetics - 1 Feb 2004
Moore Jason H
Abstract excerpt
The goal of this unit is to introduce gene-gene interactions or epistasis as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene-gene interactions and why they are likely to be common; then, it reviews several statistical and computational methods for detecting and characterizing genes whose effects are dependent on other genes. The focus of...
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