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<i>Vax2</i> regulates retinoic acid distribution and cone opsin expression in the vertebrate eye

10 Dec 2010

Abstract excerpt

Vax2 is an eye-specific homeobox gene, the inactivation of which in mouse leads to alterations in the establishment of a proper dorsoventral eye axis during embryonic development. To dissect the molecular pathways in which Vax2 is involved, we performed a transcriptome analysis of Vax2(-/-) mice throughout the main stages of eye development. We found that some of the enzymes involved in retinoic acid (RA)...

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PMID: 21148184
DOI: 10.1242/dev.051037

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