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Article

Impairing retinoic acid signalling in the neural crest cells is sufficient to alter entire eye morphogenesis.

Developmental biology - 1 Aug 2008

Matt Nicolas, Ghyselinck Norbert B, Pellerin Isabelle, Dupé Valérie

Abstract excerpt

Retinoic acid (RA) is known to be required at various levels of eye patterning via Retinoic Acid Receptors (RAR); however the molecular and cellular mechanisms triggered by these nuclear receptors are still obscure. The genetic studies performed here enable us to present a new model to study RA action during eye development. By inactivating the three RARs, specifically in the periocular mesenchyme, we...

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Identifiers

PMID: 18539269
DOI: 10.1016/j.ydbio.2008.04.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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