Article
The rax homeobox gene is mutated in the eyeless axolotl, Ambystoma mexicanum.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2021
Davis Erik S, Voss Gareth, Miesfeld Joel B, Zarate-Sanchez Juan, Voss S Randal, Glaser Tom
Abstract excerpt
BACKGROUND: Vertebrate eye formation requires coordinated inductive interactions between different embryonic tissue layers, first described in amphibians. A network of transcription factors and signaling molecules controls these steps, with mutations causing severe ocular, neuronal, and craniofacial defects. In eyeless mutant axolotls, eye morphogenesis arrests at the optic vesicle stage, before lens induction,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.