Article
Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina.
Molecular and cellular biology - 1 Jul 2003
Fan Xiaohong, Molotkov Andrei, Manabe Shin-Ichi, Donmoyer Christine M, Deltour Louise, Foglio Mario H, Cuenca Arnold E, Blaner William S, Lipton Stuart A, Duester Gregg
Abstract excerpt
Genetic studies have shown that retinoic acid (RA) signaling is required for mouse retina development, controlled in part by an RA-generating aldehyde dehydrogenase encoded by Aldh1a2 (Raldh2) expressed transiently in the optic vesicles. We examined the function of a related gene, Aldh1a1 (Raldh1), expressed throughout development in the dorsal retina. Raldh1(-/-) mice are viable and exhibit apparently normal...
Topics
- Aldehyde Oxidoreductases
- Animals
- Blotting, Southern
- Chromatography, High Pressure Liquid
- Electroretinography
- Exons
- Genotype
- Heterozygote
- Immunohistochemistry
- In Situ Hybridization
- Liver
- Mice
- Mice, Inbred C57BL