Article
Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.
PloS one - 1 Jan 2013
Paschaki Marie, Schneider Carole, Rhinn Muriel, Thibault-Carpentier Christelle, Dembélé Doulaye, Niederreither Karen, Dollé Pascal
Abstract excerpt
Retinoic acid (RA), an active derivative of the liposoluble vitamin A (retinol), acts as an important signaling molecule during embryonic development, regulating phenomenons as diverse as anterior-posterior axial patterning, forebrain and optic vesicle development, specification of hindbrain rhombomeres, pharyngeal arches and second heart field, somitogenesis, and differentiation of spinal cord neurons. This...
Topics
- Aldehyde Oxidoreductases
- Animals
- Cell Lineage
- Cluster Analysis
- Computational Biology
- Embryo, Mammalian
- Embryonic Stem Cells
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Mice
- Mice, Knockout
- Phenotype