Article

Human macula formation involves two waves of retinoic acid suppression via <i>CYP26A1</i> that modulate cell cycle exit and cone subtype specification

2024-09-19

Abstract excerpt

<h4>Summary</h4> The human macula is a specialized, cone-rich region of the eye, critical for high-acuity vision, yet the pathways regulating its development remain poorly understood. RA-catabolizing enzyme CYP26A1 establishes the chick high-acuity area via upregulation of FGF8 . However, detailed analysis of this pathway and its functions has not been performed in early human fetal tissue. Fluorescent in situ...

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Literature Corpus work: 8e89bb8b-e3ea-50e1-90e0-9579225e0f1b
DOI: 10.1101/2024.09.18.613197

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