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Article

The Cik1/Kar3 motor complex is required for the proper kinetochore-microtubule interaction after stressful DNA replication.

Genetics - 1 Feb 2011

Liu Hong, Jin Fengzhi, Liang Fengshan, Tian Xuemei, Wang Yanchang

Abstract excerpt

In budding yeast Saccharomyces cerevisiae, kinetochores are attached by microtubules during most of the cell cycle, but the duplication of centromeric DNA disassembles kinetochores, which results in a brief dissociation of chromosomes from microtubules. Kinetochore assembly is delayed in the presence of hydroxyurea, a DNA synthesis inhibitor, presumably due to the longer time required for centromeric DNA...

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Identifiers

PMID: 21135072
DOI: 10.1534/genetics.110.125468
PMCID: PMC3030485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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