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Article

Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint.

PLoS genetics - 1 Feb 2012

Jin Fengzhi, Liu Hong, Li Ping, Yu Hong-Guo, Wang Yanchang

Abstract excerpt

The attachment of sister kinetochores by microtubules emanating from opposite spindle poles establishes chromosome bipolar attachment, which generates tension on chromosomes and is essential for sister-chromatid segregation. Syntelic attachment occurs when both sister kinetochores are attached by microtubules from the same spindle pole and this attachment is unable to generate tension on chromosomes, but a...

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Identifiers

PMID: 22319456
DOI: 10.1371/journal.pgen.1002492
PMCID: PMC3271067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Loss of function of the Cik1/Kar3 motor complex results in chromosomes with syntelic attachment that are sensed by the tension checkpoint.PMID 22319456Read ↗

Histone h3 exerts a key function in mitotic checkpoint control.Semantic proximity Read ↗

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.Semantic proximity Read ↗

The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes.Semantic proximity Read ↗

The phosphorylation of a kinetochore protein Dam1 by Aurora B/Ipl1 kinase promotes chromosome bipolar attachment in yeast.Semantic proximity Read ↗

The Spc105/Kre28 complex promotes mitotic error correction by outer kinetochore recruitment of Ipl1/Sli15.Semantic proximity Read ↗

The Cik1/Kar3 motor complex is required for the proper kinetochore-microtubule interaction after stressful DNA replication.Semantic proximity Read ↗

Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control.Semantic proximity Read ↗

Laterally attached kinetochores recruit the checkpoint protein Bub1, but satisfy the spindle checkpoint.Semantic proximity Read ↗

Analysis of kinesin motor function at budding yeast kinetochores.Semantic proximity Read ↗

csi2p modulates microtubule dynamics and organizes the bipolar spindle for chromosome segregation.Semantic proximity Read ↗

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint.Semantic proximity Read ↗

Bir1 is required for the tension checkpoint.Semantic proximity Read ↗

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