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Trans-Repressive Effect of NUP98-PMX1 on PMX1-Regulated c- FOS Gene through Recruitment of Histone Deacetylase 1 by FG Repeats

1 May 2006

Abstract excerpt

The formation of fusion genes between NUP98 and members of the HOX family represents a critical factor for the genesis of acute leukemia or acute transformation of chronic myeloid leukemia (CML). To gain insights into the molecular mechanisms underlying the leukemogenesis of NUP98-HOX fusion products, we cloned NUP98-PMX1 from a CML-blast crisis patient with t(1;11) as a secondary chromosomal translocation, and...

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PMID: 16651408
DOI: 10.1158/0008-5472.can-05-3101

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