Article
The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment.
Molecular immunology - 1 Apr 2017
Geerlings Maartje J, de Jong Eiko K, den Hollander Anneke I
Abstract excerpt
Age-related macular degeneration (AMD) is a progressive retinal disease and the major cause of irreversible vision loss in the elderly. Numerous studies have found both common and rare genetic variants in the complement pathway to play a role in the pathogenesis of AMD. In this review we provide an overview of rare variants identified in AMD patients, and summarize the functional consequences of rare genetic...
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