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Article

Activation of the alternative complement pathway in vitreous is controlled by genetics in age-related macular degeneration.

Investigative ophthalmology & visual science - 25 Sept 2012

Loyet Kelly M, Deforge Laura E, Katschke Kenneth J, Diehl Lauri, Graham Robert R, Pao Lily, Sturgeon Lizette, Lewin-Koh Sock-Cheng, Hollyfield Joe G, van Lookeren Campagne Menno

Abstract excerpt

PURPOSE: To determine if the progression of age-related macular degeneration (AMD) is associated with complement activation in the eye. METHODS: Immunohistochemistry and ELISAs were used to determine the distribution, concentration, and activation of the alternative pathway complement proteases factor B (FB) and factor D (FD) and the central complement protein C3 in genotyped human postmortem donor eyes graded as...

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PMID: 22930722
DOI: 10.1167/iovs.12-9587

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CFH

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