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Article

Genetic variants in the complement system predisposing to age-related macular degeneration: a review.

Molecular immunology - 1 Oct 2014

Schramm Elizabeth C, Clark Simon J, Triebwasser Michael P, Raychaudhuri Soumya, Seddon Johanna, Atkinson John P

Abstract excerpt

Age-related macular degeneration (AMD) is a major cause of visual impairment in the western world. It is characterized by the presence of lipoproteinaceous deposits (drusen) in the inner layers of the retina. Immunohistochemistry studies identified deposition of complement proteins in the drusen as well as in the choroid. In the last decade, genetic studies have linked both common and rare variants in genes of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25034031
DOI: 10.1016/j.molimm.2014.06.032
PMCID: PMC4149817

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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