Article
Implications of genetic variation in the complement system in age-related macular degeneration.
Progress in retinal and eye research - 1 Sept 2021
de Jong Sarah, Gagliardi Giuliana, Garanto Alejandro, de Breuk Anita, Lechanteur Yara T E, Katti Suresh, van den Heuvel Lambert P, Volokhina Elena B, den Hollander Anneke I
Abstract excerpt
Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was identified as one of the main pathways contributing to disease risk. The strong link between the complement system and AMD was demonstrated by genetic associations, and by elevated complement activation in local eye tissue and in the...
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