Article
Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Mellins E, Arp B, Singh D, Carreno B, Smith L, Johnson A H, Pious D
Abstract excerpt
Allelic differences in major histocompatibility complex (MHC)-encoded class II molecules affect both the binding of immunogenic peptides to class II molecules and the recognition of MHC molecule-peptide complexes by T cells. As yet, there has been no extensive mapping of these functions to the fine structure of human class II molecules. To determine sites on the HLA-DR3 molecule involved in antigen presentation...
Topics
- Alleles
- Antigen-Presenting Cells
- Base Sequence
- Cell Line
- Clone Cells
- Gene Expression
- Genes, MHC Class II
- HLA-DR3 Antigen
- Humans
- Models, Structural
- Molecular Sequence Data