Article
Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Mellins E, Arp B, Singh D, Carreno B, Smith L, Johnson A H, Pious D
Abstract excerpt
Allelic differences in major histocompatibility complex (MHC)-encoded class II molecules affect both the binding of immunogenic peptides to class II molecules and the recognition of MHC molecule-peptide complexes by T cells. As yet, there has been no extensive mapping of these functions to the fine structure of human class II molecules. To determine sites on the HLA-DR3 molecule involved in antigen presentation...
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