The effect of a single amino acid substitution within the V3 loop of HIV-1 gp120 on HLA-DR1-restricted CD4 T-cell recognition.

Article

The effect of a single amino acid substitution within the V3 loop of HIV-1 gp120 on HLA-DR1-restricted CD4 T-cell recognition.

Immunology - 1 Jun 1995

Fernandez M H, Faith A, Higgins J A, Weber J, Rees A D

Abstract excerpt

Viral variation has been proposed to play a role in the pathogenesis of human immunodeficiency virus type-1 (HIV-1) infection, and is an important consideration in vaccine design. During the course of an infection, isolates with sequence changes in CD8 T-cell and B-cell epitopes arise. To determi...

Topics

Amino Acid Sequence
Amino Acids
CD4-Positive T-Lymphocytes
Genetic Variation
HIV Envelope Protein gp120
HLA-DR1 Antigen
Humans
Immunity, Cellular
Molecular Sequence Data

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