HLA-DR polymorphism affects the interaction with CD4.

doi:10.1084/jem.182.3.733

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Article

HLA-DR polymorphism affects the interaction with CD4.

The Journal of experimental medicine - 1 Sept 1995

Fleury S, Thibodeau J, Croteau G, Labrecque N, Aronson H E, Cantin C, Long E O, Sékaly R P

Abstract excerpt

Major histocompatibility complex (MHC) class II molecules are highly polymorphic and bind peptides for presentation to CD4+ T cells. Functional and adhesion assays have shown that CD4 interacts with MHC class II molecules, leading to enhanced responses of CD4+ T cells after the activation of the CD4-associated tyrosine kinase p56lck. We have addressed the possible contribution of allelic polymorphism in the...

Topics

Alleles
Amino Acid Sequence
Animals
Binding Sites
CD4 Antigens
CD4-Positive T-Lymphocytes
H-2 Antigens
HLA-DR Antigens
Histocompatibility Antigen H-2D
Humans
Hybridomas

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-2

Mice

Models, Molecular

Molecular Sequence Data

Polymorphism, Genetic

Protein Conformation

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 7650480
DOI: 10.1084/jem.182.3.733
PMCID: PMC2192178

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7650480-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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