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Article

HLA-DR polymorphism affects the interaction with CD4.

The Journal of experimental medicine - 1 Sept 1995

Fleury S, Thibodeau J, Croteau G, Labrecque N, Aronson H E, Cantin C, Long E O, Sékaly R P

Abstract excerpt

Major histocompatibility complex (MHC) class II molecules are highly polymorphic and bind peptides for presentation to CD4+ T cells. Functional and adhesion assays have shown that CD4 interacts with MHC class II molecules, leading to enhanced responses of CD4+ T cells after the activation of the CD4-associated tyrosine kinase p56lck. We have addressed the possible contribution of allelic polymorphism in the...

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Identifiers

PMID: 7650480
DOI: 10.1084/jem.182.3.733
PMCID: PMC2192178

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DAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HLA-DR polymorphism affects the interaction with CD4.PMID 7650480Read ↗

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