Article
Rewiring of genetic networks in response to DNA damage.
Science (New York, N.Y.) - 3 Dec 2010
Bandyopadhyay Sourav, Mehta Monika, Kuo Dwight, Sung Min-Kyung, Chuang Ryan, Jaehnig Eric J, Bodenmiller Bernd, Licon Katherine, Copeland Wilbert, Shales Michael, Fiedler Dorothea, Dutkowski Janusz, Guénolé Aude, van Attikum Haico, Shokat Kevan M, Kolodner Richard D, Huh Won-Ki, Aebersold Ruedi, Keogh Michael-Christopher, Krogan Nevan J, Ideker Trey
Abstract excerpt
Although cellular behaviors are dynamic, the networks that govern these behaviors have been mapped primarily as static snapshots. Using an approach called differential epistasis mapping, we have discovered widespread changes in genetic interaction among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage. Differential interactions uncover many gene functions that go...
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