Article
Environmental robustness of the global yeast genetic interaction network.
Science (New York, N.Y.) - 7 May 2021
Costanzo Michael, Hou Jing, Messier Vincent, Nelson Justin, Rahman Mahfuzur, VanderSluis Benjamin, Wang Wen, Pons Carles, Ross Catherine, Ušaj Matej, San Luis Bryan-Joseph, Shuteriqi Emira, Koch Elizabeth N, Aloy Patrick, Myers Chad L, Boone Charles, Andrews Brenda
Abstract excerpt
Phenotypes associated with genetic variants can be altered by interactions with other genetic variants (GxG), with the environment (GxE), or both (GxGxE). Yeast genetic interactions have been mapped on a global scale, but the environmental influence on the plasticity of genetic networks has not been examined systematically. To assess environmental rewiring of genetic networks, we examined 14 diverse conditions...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.