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Article

Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift.

Diabetes - 1 Aug 2007

Röckl Katja S C, Hirshman Michael F, Brandauer Josef, Fujii Nobuharu, Witters Lee A, Goodyear Laurie J

Abstract excerpt

Regular endurance exercise has profound benefits on overall health, including the prevention of obesity, cardiovascular disease, and diabetes. The objective of this study was to determine whether AMP-activated protein kinase (AMPK) mediates commonly observed adaptive responses to exercise training in skeletal muscle. Six weeks of voluntary wheel running induced a significant (P < 0.05) fiber type IIb to IIa/x...

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Identifiers

PMID: 17513699
DOI: 10.2337/db07-0255

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