Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sexually dimorphic skeletal muscle and cardiac dysfunction in a mouse model of limb girdle muscular dystrophy 2i.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 2017

Maricelli Joseph W, Kagel Denali R, Bishaw Yemeserach M, Nelson O Lynne, Lin David C, Rodgers Buel D

Abstract excerpt

The fukutin-related protein P448L mutant mouse replicates many pathologies common to limb girdle muscular dystrophy 2i (LGMD2i) and is a potentially strong candidate for relevant drug screening studies. Because striated muscle function remains relatively uncharacterized in this mouse, we sought to identify metabolic, functional and histological metrics of exercise and cardiac performance. This was accomplished by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Echocardiography, Doppler
Share to Exercise Tolerance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Muscle Strength

Share to Muscular Dystrophies, Limb-Girdle

Share to Pentosyltransferases

Share to Running

Share to Transferases

Source

Identifiers

PMID: 28663375
DOI: 10.1152/japplphysiol.00287.2017

Genes

FKRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sexually dimorphic skeletal muscle and cardiac dysfunction in a mouse model of limb girdle muscular dystrophy 2i.PMID 28663375Read ↗

Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progressionSemantic proximity Read ↗

Proteomic profiling uncovers sexual dimorphism in the muscle response to wheel running exercise in the FLExDUX4 murine model of facioscapulohumeral muscular dystrophySemantic proximity Read ↗

Progressive Dystrophic Pathology in Diaphragm and Impairment of Cardiac Function in FKRP P448L Mutant Mice.Semantic proximity Read ↗

Cardiac and respiratory failure in limb-girdle muscular dystrophy 2I.Semantic proximity Read ↗

Noninvasive, in vivo approaches to evaluating behavior and exercise physiology in mouse models of mitochondrial disease.Semantic proximity Read ↗

Histopathology and spatial transcriptomics jointly map myofiber-specific pathological programs in mTORC1-driven myopathySemantic proximity Read ↗

Asleep at the Wheel: Forward Genetic ENU Mutagenesis Screen for Mouse Models of Chronic Fatigue Identifies a Mutation in <i>Slc2a4</i> (GLUT4)Semantic proximity Read ↗

Humanization of the mdx Mouse Phenotype for Duchenne Muscular Dystrophy Modeling: A Metabolic Perspective.Semantic proximity Read ↗

Mouse sarcopenia model reveals sex- and age-specific differences in phenotypic and molecular characteristics.Semantic proximity Read ↗

Subepicardial dysfunction leads to global left ventricular systolic impairment in patients with limb girdle muscular dystrophy 2I.Semantic proximity Read ↗

Modifiers of heart and muscle function: where genetics meets physiology.Semantic proximity Read ↗

Muscular dystrophy in dysferlin-deficient mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.