Article

Miro1 Mediates Skeletal Muscle Insulin Resistance in Type 2 Diabetes

2025-08-10

Abstract excerpt

<h4> ABSTRACT </h4> Imbalanced skeletal muscle mitochondrial dynamics contributed to the onset and progression of type 2 diabetes (T2D) by mechanisms that remained incompletely understood. Here, we examined the role of mitochondrial Rho GTPase 1 (Miro1), an outer mitochondrial membrane enzyme, in the regulation of skeletal muscle insulin action and glucose homeostasis in T2D. Miro1 accumulated in the skeletal mu...

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Literature Corpus work: 0667820d-2e3b-5632-a08e-0ffc35eb5d5b
DOI: 10.1101/2025.08.06.25333143

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