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Article

Calcineurin Regulates Skeletal Muscle Metabolism via Coordinated Changes in Gene Expression

16 Nov 2006

Abstract excerpt

The metabolic property of skeletal muscle adapts in response to an increased physiological demand by altering substrate utilization and gene expression. The calcium-regulated serine/threonine protein phosphatase calcineurin has been implicated in the transduction of motor neuron signals to alter gene expression programs in skeletal muscle. We utilized transgenic mice that overexpress an activated form of...

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PMID: 17107952
DOI: 10.1074/jbc.m609208200

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